Tyroserleutide 是一种可从猪脾脏的降解产物中分离得到的小分子三肽，在体内外均对肿瘤生长具有抑制作用。

Tyroserleutide (YSL), isolated from the degradation products of porcine spleen, is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo.Tyroserleutide inhibits the growth and metastasis of human hepatocellular carcinoma (HCC).

Tyroserleutide (YSL) has immuno-modulating effects, like enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells[1]. Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression[2]. Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells[2]. Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration[2].

138168-48-6

C18H27N3O6

381.42

H2O:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years