产品描述
BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer activity[1].
体外活性
BI-3663 potently degrades PTK2 in Hep3B2.1-7 cells, and A549 cells, with pDC50s of 7.6 and 7.9, respectively[1].
Cas No.
2341740-84-7
分子式
C44H42F3N7O12
分子量
917.84
储存和溶解度
DMSO:300 mg/mL (326.85 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
