Furafylline 是有选择性的人细胞色素P450IA2抑制剂(IC50:0.07 μM)。
产品描述
Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM),
体外活性
Furafylline was a potent, non-competitive inhibitor of high affinity phenacetin O-deethylase activity of microsomal fractions of human liver, a reaction catalysed by P450IA2, with an IC50 value of 0.07 microM[1].
体内活性
Furafylline was originally introduced as a bronchodilator with extended duration compared to theophylline[1].
Cas No.
80288-49-9
分子式
C12H12N4O3
分子量
260.253
别名
呋喃茶碱;呋拉茶碱
储存和溶解度
DMSO:12.5 mg/mL (48.03 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
