Diclofenac potassium 是一种非甾体抗炎药，用于减轻炎症并在某些情况下作为镇痛剂减轻疼痛。它通过活化 Caspase 级联反应来诱导神经干细胞凋亡。它是一种COX抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM和0.84 μM。

Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

15307-81-0

C14H10Cl2KNO2

334.24

Voltfast;双氯芬酸钾;Cataflam;CGP-45840B

H2O:10 mg/mL (29.91 mM)
Ethanol:<1 mgml
DMSO:64 mg/mL (191.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years