BMS-191095是一种线粒体ATP敏感性的钾离子通道活化剂。
产品描述
BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.
体外活性
BMS-191095 elicits a dose-dependent vasodilation in endothelium-denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. BMS-191095 induces mitochondrial-depolarization and vasodilation.
体内活性
In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.
Cas No.
166095-21-2
分子式
C22H21ClN4O2
分子量
408.88
储存和溶解度
DMSO:90 mg/mL (220.11 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
