Ralfinamide 是一种具有口服活性的，来源于 α-aminoamide 的钠离子通道阻滞剂, 在缓解疼痛方面有研究的价值。
产品描述
Ralfinamide is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.
体内活性
Oral ralfinamide dose-dependently alleviated spared nerve injury-induced allodynia in rats and mice. Ralfinamide increased mechanical withdrawal thresholds in oxaliplatin-induced and paclitaxel-induced neuropathic pain. Ralfinamide did not affect physiological pain, locomotion,or cardiovascular function[1].
Cas No.
133865-88-0
分子式
C17H19FN2O2
分子量
302.349
别名
(S)-2-[[4-[(2-氟苄基)氧基]苄基]氨基]丙酰胺;Priralfinamide;FCE-26742A
储存和溶解度
DMSO:125 mg/mL (413.44 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
