MRT-81 是一种人和啮齿动物 smoothened 受体的有效拮抗剂，能够抑制 hedgehog 的活性，在 Shh-light2 细胞中的IC50值为 41 nM。它可用于研究癌症。
产品描述
MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cancer[1].
体外活性
MRT-81 inhibits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatase positive osteoblasts induced by the Smo agonist SAG with 0.1 μM, with an IC50?value of 64 nM[1].
Cas No.
1263132-08-6
分子式
C31H29N3O5S
分子量
555.65
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
