DMU-212 是具有口服活性的白藜芦醇的甲基化衍生物，表现出抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。它通过诱导凋亡和激活ERK1/2蛋白阻止有丝分裂。
产品描述
DMU-212, a methylated form of Resveratrol, shows antimitotic, antiproliferative, and antioxidant activities. DMU-212 induces mitotic arrest through the activation of ERK1/2 protein and the promotion of apoptosis.
体外活性
DMU-212 (0.3125-40 μM) inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC50=0.5 μM, 0.5 μM, 1.25 μM, and 1.25 μM for A375, Bro, MeWo, and M5 human melanoma cells, respectively.)[2].
体内活性
In SCID female mice, DMU-212 (50 mg/kg; i.g.) inhibited tumor growth and lowered tumor burden[2].
Cas No.
134029-62-2
分子式
C18H20O4
分子量
300.35
储存和溶解度
DMSO:20 mg/mL (66.59 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
