UC-112是凋亡抑制蛋白IAP新型高效抑制剂，癌细胞IC50值0.7-3.4uM。
产品描述
UC-112 is a novel potent IAP inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).
体外活性
UC-112 also effectively inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112[1].
体内活性
UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo [1].
Cas No.
383392-66-3
分子式
C22H24N2O2
分子量
348.44
储存和溶解度
DMSO:30.6mg/mL (87.8mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
