LH-RH, salmon acetate(86073-88-3 free base) 是一种在下丘脑中合成的垂体激素,在控制生殖功能中起着至关重要的作用。
产品描述
Luteinizing Hormone Releasing Hormone (LH-RH) acetateis a pituitary Hormone synthesized in the hypothalamus and plays a crucial role in the control of reproductive function.
体外活性
Luteinizing hormone-releasing hormone (LHRH) is the key hormone in the control of reproductive functions.LHRH acts as an antimitogenic factor through the activation of the Gi-cAMP intracellular signaling pathway. LHRH might act as an inhibitory factor on both cell proliferation and metastatic behavior in melanoma cells[1]. The hypothalamic decapeptide luteinizing hormone-releasing hormone (LHRH) plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn promote gonadal functions and regulate sex steroid secretion. The effects of LHRH are mediated by high-affinity G protein-coupled LHRH-receptor (LHRH-R) on pituitary gonadotropes. The responses to LHRH vary under different conditions and critically depend on the regimens of administration and doses delivered to gonadotrope cells[2].
Cas No.
TP1112L
分子式
C62H77N15O15
分子量
1272.35
别名
Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years