Shz-1在 P19CL6 细胞中诱导各种心脏特异性基因，包括肌节原肌球蛋白，在小鼠中诱导 Nkx2.5 表达。Shz-1 在 C2C12 细胞中激活轴突 TPM4 启动子驱动的异位表达。
产品描述
Shz 1 is a cardiogenic agent that induces phenotypic differentiation and various cardiac-specific genes including sarcomeric tropomyosin.
体外活性
Shz-1 showes a ~1.5-fold increase in cardiac transcripts of the Nkx2.5 gene. Shz-1 augments the expression of transcripts of the total sarcomeric TPM1 (both TPM1α & TPM1κ) and sarcomeric TPM4α. Shz-1 activates the axolotl TPM4 promoter-driven ectopic expression in C2C12 cells[1].
Cas No.
326886-05-9
分子式
C13H11BrN2O3S
分子量
355.21
储存和溶解度
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
