BMS-986235 是一种特异性和口服活性的甲酰肽受体 2 (FPR2) 激动剂，对 hFPR2 和 mFPR2 的 EC50 分别为 0.41 nM 和 3.4 nM。 BMS-986235 可用于预防心力衰竭的研究。

BMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure.

BMS-986235 inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, thereby promoting resolution of inflammation[1].

In male C57BL/6 mice, BMS-986235 (0.3 mg/kg; p.o.) attenuates left ventricle and global cardiac remodeling after left anterior descending and reduces infarct length by 39% relative to the vehicle. BMS-986235 (1 mg/kg; p.o.) shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/Loh, and 24%, respectively[1].

2253947-47-4

C18H17F2N3O3

361.34

LAR-1219;BMS-986235

DMSO:95 mg/mL (262.91 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years