| CAS NO: | 442632-72-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 询价 |
| 10mg | 询价 |
| 25mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
| 250mg | 询价 |
| 1g | 询价 |
| Molecular Weight (MW) | 284.38 |
|---|---|
| Formula | C16H16N2OS |
| CAS No. | 442632-72-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 57 mg/mL (200.4 mM) |
| Water: <1 mg/mL | |
| Ethanol: 50 mg/mL (175.8 mM) | |
| Other info | Chemical Name: N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide InChi Key: ACAKNPKRLPMONU-UHFFFAOYSA-N InChi Code: InChI=1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19) SMILES Code: O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3 |
| Synonyms | CK0944636; CK636; CK-0944636; CK 636; CK 0944636; CK-636 |
| In Vitro | In vitro activity: CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Nature. 2009 Aug 20;460(7258):1031-4; PLoS One. 2013 Sep 12;8(9):e73960. |
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