AGX51 是 DNA 结合蛋白抑制剂 (ID) 的拮抗剂。 AGX51 治疗导致泛 Id 降解、细胞周期停滞和细胞死亡。
产品描述
AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.
体外活性
AGX51 inhibits the Id1-E47 interaction. AGX51 is well-tolerated in mice and phenocopies the genetic loss of Id expression in AMD and ROP models by inhibiting retinal neovascularization. AGX51 may have utility in the management of multiple diseases[1].
Cas No.
330834-54-3
分子式
C27H29NO4
分子量
431.52
储存和溶解度
Ethanol:95 mg/mL (220.15 mM),Need ultrasonic
DMSO:95 mg/mL (220.15 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
