Oxyphenisatin acetate 是oxyphenisatin的前体药物，可抑制乳腺癌细胞系 MCF7、T47D、HS578T 和 MDA-MB-468 的生长。
产品描述
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.
体外活性
In the estrogen receptor (ER) positive MCF7 and T47D cells, OXY induced TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Lastly, in an MCF7 xenograft model, OXY delivered intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1. OXY induces a multifaceted cell starvation response, which ultimately induces programmed cell death[1].
细胞实验
Total RNA was isolated from MCF7 cells treated with 10 μmol/L OXY for 24 h and the microarray procedure performed as described previously using the GeneChip Human U133 plus 2.0 array . Pairwise analysis was performed on control versus treated arrays using a fivefold change cutoff,<0.01 adjusted P-value, GC-RMA normalization with Benjamini–Hochberg false discovery estimation[1].
Cas No.
115-33-3
分子式
C24H19NO5
分子量
401.41
储存和溶解度
DMSO:150 mg/mL (373.68 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
