E67-2, as the E67 derivative, is a low-toxicity, selective KIAA1718 Jumonji domain inhibitor with an IC 50 value of 3.4 μM. E67-2 selectively inhibits histone H3 lysine 9 ( H3K9 ) Jumonji demethylase as well as histone H3 lysine 4 ( H3K4 ) demethylase.

E67-2 (1~100 μM; 5 minutes) reduces inhibitory effect against GLP by a factor of approximately 1500, resulting in an IC 50 of 75 μM. E67-2 has much reduced inhibition on PHF8 on the doubly methylated H3(1-24)K4me3K9me2 peptide substrate. E67-2 (100~100000 nM; 24 hours; fibroblasts) has significantly reduced cell toxicity[1].

1364914-62-4

C21H36N6O2

404.55

E67-2

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years