VU6012962 是一种可渗透 CNS ，可口服的代谢型谷氨酸受体 7 阴性变构调节剂，IC50为 347 nM。
产品描述
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
体外活性
Compared to the other seven mGlu receptor subtypes, VU6012962 is highly selective for mGlu7.
体内活性
In the elevated zero maze (EZM) assay in mice, VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety .
Cas No.
2313526-86-0
分子式
C21H19F3N4O4
分子量
448.4
储存和溶解度
DMSO:125 mg/mL (278.77 mM),Need ultrasonic
H2O:< 0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
