MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L, and Cat S.

MK-0674 is effective in bone resorption in rabbit osteoclasts (IC50: 10 nM).

887781-62-6

C26H27F6N3O2

527.5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years