CDK4/6-IN-6 是CDK4/CDK6的有效抑制剂，结合CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 为 0.6 nM 和 13.9 nM。

CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.

Using phosphorylated Rb S795 ELISA assay in JEKO-1 cells, CDK4/6-IN-6 has IC50s of 38.5 nM for CDK4/Cyclin D1 and 144.9 nM for CDK6/Cyclin D3, respectively [1].

2380321-51-5

C22H27ClFN5O3

463.94

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years