Duocarmycin analog-2 是一种有效的 DNA 烷基化剂。Duocarmycin analog-2 可用于合成免疫偶联物。Duocarmycin analog-2 具有抗肿瘤活性。
产品描述
Duocarmycin analog-2 is a potent DNA alkylating agent. Duocarmycin analog-2 can be used of synthetic immunoconjugate. Duocarmycin analog-2 has antitumor activity [1].
体外活性
Duocarmycin analog-2 (72 h) has anti-proliferative activity with IC 50 values of 0.001, 0.002, 0.002, 0.004, 0.009, 0.01, 0.015, 0.019, 0.019, 0.019, 0.02, 0.04, and 0.068 nM for DU4475, SET2, HCT 16, A2780, MDA MB468, LNCaP, LS174T, CCRF-CEM, COLO205, H2087, H661, A549, and MCD MB231 cells, respectively.
Cas No.
1164275-01-7
分子式
C29H23ClN4O3
分子量
510.97
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
