CID 5951923 是 KLF5 转录因子的抑制剂，IC50 为 603 nM。
产品描述
CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.
体外活性
CID 5951923 (10 μM) inhibits the proliferation of cancer cell lines mainly in highly expressing KLF5 cells. CID 5951923 (0.001, 0.01, 0.1, 1, 10, 100 μM) inhibits proliferation of DLD-1 cells in a dose-dependent manner. CID 5951923 (10 μM) significantly decreases endogenous KLF5 levels in the DLD-1 cells, downregulates EGR1, and increases phosphorylation levels of pEGFFpY1068[1].
Cas No.
749872-43-3
分子式
C16H18N2O7S
分子量
382.39
储存和溶解度
DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
