LEP(116-130)(mouse) 是合成的瘦素肽片段之一。

Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis.

LEP-(116-130) (300 μM) is unable to inhibit AP-OB binding. Moreover, LEP-(116-130) was unable to activate signal transduction by OB-Rb in vitro[1].

LEP-(116-130) (1 mg, i.p.) results in a reduced rate of body weight gain in the presence of increased food intake than vehicle-injected control mice. LEP-(116-130) significantly reduces blood glucose levels by appr 100 mg/dL. Administration of LEP-(116-130) to wild-type (+/+) C57BLKS/J-m mice for 4 or 7 days has no effect on their ability to thermoregulate[1].

258276-95-8

C64H109N19O24S

1560.75

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