NSC 617145 是一种 WRN 解旋酶抑制剂，IC50值为 230 nM。它以浓度依赖性方式抑制 WRN 解旋酶的 ATP 酶，并诱导双链断裂和染色体异常。
产品描述
NSC617145 is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.
体外活性
NSC 617145 inhibits growth of HeLa cells via formation of DNA double strand breaks (DSBs) and induction of apoptosis in a WRN helicase-dependent manner. NSC 617145 also acts synergistically with mitomycin C to inhibit growth as well as induce DSBs and chromosomal abnormalities in Fanconia-anemia deficient (FA-D2-/-) cells.
Cas No.
203115-63-3
分子式
C13H10Cl4N2O4
分子量
400.03
别名
NSC617145;NSC-617145
储存和溶解度
DMSO:6 mg/ml (15 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
