NMDAR/HDAC-IN-1 (Compound 9d) 是一种NMDAR和HDAC双重抑制剂，对 NMDAR 的Ki值为 0.59 μM，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的IC50分别为 2.67、8.00、2.21、0.18 和 0.62 μM。NMDAR/HDAC-IN-1 能有效穿透血脑屏障。

NMDAR/HDAC-IN-1 (Compound 9d) is a dual NMDAR and HDAC inhibitor with a K i of 0.59 μM for NMDAR and IC 50 values of 2.67, 8.00, 2.21, 0.18 and 0.62 μM for HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8, respectively. NMDAR/HDAC-IN-1 efficiently penetrates the blood brain barrier [1].

NMDAR/HDAC-IN-1 (Compound 9d) increases the level of AcTubulin in MV4-11 cells and rescues PC-12 cells from H 2 O 2 -induced cytotoxicity with EC 50 of 0.94 μM [1].

C22H28N2O3

368.47

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years