Azimilide dihydrochloride 是 I(Ks) 和 I(Kr) 抑制剂，具有抗心律失常活性。
产品描述
Azimilide Dihydrochloride, a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current
体内活性
Azimilide has shown excellent efficacy (>85%) in suppressing supraventricular arrhythmias in a variety of dog models.?It also suppressed complex ventricular arrhythmias in infarcted dogs and, in a sudden death cardiac model, decreased mortality[1].
Cas No.
149888-94-8
分子式
C23H30Cl3N5O3
分子量
530.88
别名
盐酸阿齐利特;NE-10064 Dihydrochloride
储存和溶解度
DMSO:8.46 mg/mL (15.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
