MTIC is a DNA alkylating agent, an active metabolite of dacarbazine, and an active degradation product of temozolomide.[1],[2],[3] MTIC is cytotoxic to L-cells and decreases thymidine and uridine uptake by 55 and 65%, respectively, when used at a concentration of 1 mM.[2] It is also cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner.[3]

In vivo, MTIC induces formation of mammary adenofibromas in rats when administered at a cumulative dose of 890 mg per animal over 14 weeks.[4]

3413-72-7

C5H8N6O

168.16

NSC 407347;MTIC;MTIC

DMSO:Slightly soluble
Methanol:Slightly soluble,Heated
Powder: -20°C for 3 years
In solvent: -80°C for 2 years