SJ572403 是一种无序蛋白 p27 的抑制剂，对于 p27-KID 的 D2 亚结构域内的特定区域的 Kd 为 2.2 mM。 SJ572403 可用于研究具有内在无序蛋白质的疾病。
产品描述
SJ572403 is an inhibitor of disordered protein p27 with Kd of 2.2 mM for specific regions within the D2 subdomain of p27-KID. SJ572403 can be used in studies about diseases with intrinsically disordered proteins.
体外活性
SJ572403 (10 μM-3 mM) replaces p27-D2 on Cdk2/cyclin A and partially restores Cdk2 kinase activity. SJ572403 (0-3 mM) modulates Cdk regulation of p27[1].
Cas No.
19970-45-7
分子式
C13H17N5O2
分子量
275.31
别名
SJ403;SJ572403
储存和溶解度
DMSO:12.5mg/mL (45.4mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
