Calcifediol 是由维生素 D3 在肝中经羟基化后得到的前激素，是VDR的有效抑制剂。
产品描述
Calcifediol(Ki of 3.9 μM), a major circulating metabolite of vitamin D3, works as a competitive inhibitor. It (ED50=2 nM)also inhibits PTH secretion and mRNA.
体外活性
Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes shows a significant reduction result in bacterial survival[1].
Cas No.
19356-17-3
分子式
C27H44O2
分子量
400.647
别名
U 32070E;RO 8-8892;25-羟基维生素 D3;骨化二醇;25-hydroxy Vitamin D3;Calcifediol
储存和溶解度
Ethanol:16 mg/mL (39.9 mM)
DMSO:74 mg/mL (184.7 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
