TMN355 是一种化学亲环素 A 抑制剂，能够抑制泡沫细胞形成和细胞因子分泌，可用于动脉粥样硬化的研究。
产品描述
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis.
体外活性
Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.?The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p
Cas No.
1186372-20-2
分子式
C21H14ClFN2O2
分子量
380.8
别名
2-氯-N-[(9H-芴-9-氨基)羰基]-6-氟苯甲酰胺;TMN355
储存和溶解度
DMSO:31.25 mg/mL (82.06 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
