(R)-MLT-985 (compound 11) 是一种有效的MALT1蛋白酶抑制剂，IC50为 3 nM。(R)-MLT-985 在 Jurkat 细胞中对 MALT1 依赖性 IL-2 的 IC50为 20 nM。(R)-MLT-985 抑制 ABC-DLBCL 细胞中的生长和异常 CARD11/BCL10/MALT1 复合物信号传导。

(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC 50 of 3 nM. (R)-MLT-985 has an IC 50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells [1].

1832577-07-7

C17H15Cl2N9O2

448.27

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years