H-Leu-Leu-OMe . HBr 是由人单核细胞或多形核白细胞产生的L-亮氨酸甲酯的二肽缩合产物。 H-Leu-Leu-OMe . HBr 诱导内溶酶体途径应激并选择性地消除具有细胞毒性潜力的淋巴细胞。
产品描述
H-Leu-Leu-OMe . HBr is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes. H-Leu-Leu-OMe . HBr induces endolysosomal pathway stress and selectively eliminates lymphocytes with cytotoxic potential.
体外活性
H-Leu-Leu-OMe . HBr (10-250 μM; 15 min) is converted to a CCI3COOH-insoluble product by CD4- lymphocytes[1]. H-Leu-Leu-OMe . HBr (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells[2].
Cas No.
T36879L
分子式
C15H31BrN2O5
分子量
399.32
别名
H-Leu-Leu-OMe . HBr (16689-14-8 Free base);H-Leu-Leu-OMe . HBr
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years