BPK-29 hydrochloride 是特殊配体，能够共价修饰 C274 ，破坏非典型孤核受体NR0B1与RBM45、SNW1蛋白质的相互作用。它能够损害KEAP1突变癌细胞的锚定独立生长。
产品描述
BPK-29 hydrochloride is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein interactions by covalently modifying C274. It impairs the anchorage-independent growth of KEAP1-mutant cancer cells.
体外活性
BPK-29 substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].
Cas No.
2444815-73-8
分子式
C26H33Cl2N3O3
分子量
506.46
别名
BPK-29 hydrochloride
储存和溶解度
DMSO:62.5 mg/mL (123.41 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
