Lenacapavir 是一种有效的靶向衣壳的 HIV 复制抑制剂。 Lenacapavir 在 MT-4 细胞中显示出抗 HIV 活性，EC50 为 100 pM。
产品描述
Lenacapavir is a potent capsid-targeting inhibitor of HIV replication. Lenacapavir shows anti-HIV activity with an EC50 of 100 pM in MT-4 cells.
体外活性
Lenacapavir displays a mean EC50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells. Lenacapavir shows sub-nanomolar potency in target cells with EC50 of 23 pM, in a full-cycle assay with EC50 of 25 pM and in producer cells with EC50 of 439 pM[2].
Cas No.
2189684-44-2
分子式
C39H32ClF10N7O5S2
分子量
968.28
别名
GS-6207;Lenacapavir
储存和溶解度
DMSO:195 mg/mL (201.39 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
