FEN1 Inhibitor C2 是人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。

FEN1-IN-4 is an inhibitor of human flap endonuclease-1 (hFEN1)

FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.

1995893-58-7

C12H12N2O3

232.239

FEN1 Inhibitor C2;FEN1-IN-4

DMSO:100 mg/mL (430.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years