K783-0308 是一种有效且选择性的FLT3和MNK2双重抑制剂，IC50值分别为 680 和 406 nM。 K783-0308 抑制 MOLM-13 (IC50=10.5 μM) 和 MV-4-11 (IC50=10.4 μM) 细胞的生长。K783-0308 促进急性髓性白血病 (AML) 细胞的Apoptosis" style="display: inline; color: #c13a36">凋亡 (Apoptosis) 并使细胞周期停滞在 G0/G1 期。

K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC 50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC 50 =10.5 μM) and MV-4-11 (IC 50 =10.4 μM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase [1].

K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC 50 =10.5 μM) and MV-4-11 (IC 50 =10.4 μM) cells [1]. K783-0308 (1, 3, 10, 30 μM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase [1]. Cell Cytotoxicity Assay [1] Cell Line: MOLM-13, MV-4-11 cells (RPMI-1640 supplemented with streptomycin (100 μg/mL)/penicillin (100 U/mL)/ amphotericin B (0.25 μg/mL)) Concentration: 1, 3, 10, 30 μM Incubation Time: 48 h, 72 h Result: Promotes AML cell apoptosis and cell cycle arrested in the G0/G1 phase.

422554-29-8

C21H23N3O

333.43

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years