PSI-7976 is the isomer of PSI-7977. In the HCV replicon assay, PSI-7977 is an active inhibitor of HCV RNA replication, demonstrates effective anti-hepatitis C virus (HCV) activity.

PSI-7851 is a mixture of two diastereoisomers, PSI-7976 and PSI-7977. In the HCV replicon assay, with PSI-7977 being the more active inhibitor of HCV RNA replication. The kinetic data also indicates that PSI-7976 is a better substrate for CES1 than for cathepsin A (CatA). Carboxylesterase 1 (CES1) preferentially hydrolyzes PSI-7976 over PSI-7977 [1]

1190308-01-0

C22H29FN3O9P

529.45

PSI-7976

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years