GPNA hydrochloride 是一种 γ-谷氨酰转移酶的知名底物，可逆地诱导 A549 细胞凋亡。它是一种特定的谷氨酰胺转运蛋白ASCT2抑制剂，还抑制依赖 Na+的载体，如 SNAT 家族 (SNAT1/2/4/5) 和不依赖 Na+的亮氨酸转运蛋白 LAT1/2。
产品描述
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.
体外活性
GPNA hydrochloride is a glutamine transporter ASCT2 inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers.
Cas No.
67953-08-6
分子式
C11H14ClN3O5
分子量
303.7
别名
GPNA hydrochloride
储存和溶解度
DMSO:124 mg/mL(408.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
