Solabegron 是一种β3肾上腺素能受体 (β3-AR)的选择性激动剂, 在中国仓鼠卵巢细胞中测得EC50=22 nM，可用于研究膀胱过度活跃和肠易激综合征。
产品描述
Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome.
体内活性
Solabegron(3 mg/kg i.v.)evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs.
Cas No.
252920-94-8
分子式
C23H23ClN2O3
分子量
410.89
别名
3'-[[2-[(2R)-2-(3-氯苯基)-2-羟基乙基]氨基]乙基]氨基]-[1,1'-联苯基]-3-羧酸;GW 427353;Solabegron
储存和溶解度
DMSO:250 mg/mL (608.44 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
