DS-1971a 是选择性、口服有效的NaV1.7抑制剂，对 hNaV1.7 和 mNaV1.7 的IC50分别为 22.8 和 59.4 nM。DS-1971a在缓解疼痛方面有研究价值。
产品描述
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
体外活性
DS-1971a showed high NaV1.7 inhibitory potency in vitro. The IC50 values are of 22.8 nM for hNaV1.7 and 59.4 mM for mNaV1.7[1].
体内活性
DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice with ED50 of 0.32 mg/kg[1].
Cas No.
1450595-86-4
别名
DS-1971a
储存和溶解度
DMSO:100 mg/mL (214.62 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
