DX2-201 是一种有效的选择性氧化磷酸化 (OXPHOS) 复合物 I 抑制剂，IC50为 312 nM。DX2-201 具有抗癌作用。

DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC 50 of 312 nM. DX2-201 has anticancer effects [1].

DX2-201 (cmpound 2) potently inhibits the mitochondrial function by depleting ATP production in MIA PaCa-2 cells when glucose is replaced by galactose in the medium, a condition that forces mammalian cells to rely on OXPHOS [1]. DX2-201 depletes ATP production with an IC 50 value of 118.5 nM in the galactose-containing medium [1]. DX2-201 significantly inhibits OXPHOS complex I as determined by its inhibition of oxidation of NADH to NAD+ in the NAD/NADH assay (IC 50 = 312 nM) [1]. DX2-201 inhibits MIA PaCa-2 and BxPC-3 cells growth with IC 50 values of 0.4 μM and 0.6 μM, respectively [1].

2749554-00-3

C18H28N2O6S2

432.55

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years