SGN-2FF 是一种岩藻糖基化抑制剂，具有口服活性，能够抑制岩藻糖基转移酶的活性，具有抗肿瘤活性。

SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.

SGN-2FF is a fucosylation inhibitor, SGN-2FF inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of fucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner.

In multiple mouse tumor models, SGN-2FF exhibits antitumor activity. SGN-2FF shows substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model.

2089647-47-0

C6H11FO4

166.15

SGN-2FF

H2O:35 mg/mL (210.65 mM),Need ultrasonic
DMSO:50 mg/mL (300.93 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years