VU0119498 是泛 GqmAChR M1、M3和M5的正变构调节剂，具有抗糖尿病活性，EC50值分别为 6.04、6.38 和 4.08 μM。
产品描述
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
体内活性
VU0119498 treatment of wild-type mice caused a significant increase in plasma insulin levels, accompanied by a striking improvement in glucose tolerance
Cas No.
79183-37-2
分子式
C15H10BrNO2
分子量
316.15
别名
VU0119498
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
