Seltorexant hydrochloride is a selective, orally active and high-affinity antagonist of OX2R with pKi values of 8.0 and 8.1 for human and rat OX2R.

Seltorexant hydrochloride (JNJ-42847922 hydrochloride) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats. The sleep-promoting effects of Seltorexant hydrochloride (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats.

1293284-49-7

C21H23ClFN7O

443.91

JNJ-42847922 hydrochloride;Seltorexant hydrochloride

DMSO:83.33 mg/mL (187.72 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years