Lasmiditan hydrochloride 是一种新型、中枢作用、高选择性的 5-HT(1F) 受体激动剂 (K1:2.21 μM)。
产品描述
Lasmiditan hydrochloride is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1:2.21 μM)
体外活性
Lasmiditan, a novel serotonin1F receptor agonist, showed specific affinity in vitro for the receptor without any vasoconstrictive action and inhibited markers associated with electrical stimulation of trigeminal ganglion in migraine animal models[1].
Cas No.
613677-28-4
分子式
C19H19ClF3N3O2
分子量
413.83
别名
COL-144 hydrochloride;LY 573144 hydrochloride;Lasmiditan hydrochloride
储存和溶解度
DMSO:28 mg/mL (67.66 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
