| CAS NO: | 23327-57-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 10mg | 询价 |
| 25mg | 询价 |
| 50mg | 询价 |
| 100mg | 询价 |
| 250mg | 询价 |
| 500mg | 询价 |
| 1g | 询价 |
| Molecular Weight (MW) | 289.8 |
|---|---|
| Formula | C17H19NO.HCl |
| CAS No. | 23327-57-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: <1 mg/mL |
| Water: 21 mg/mL (72.5 mM) | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride InChi Key: CNNVSINJDJNHQK-UHFFFAOYSA-N InChi Code: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H SMILES Code: CN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3C1.[H]Cl |
| Synonyms | Leoplexamin; Nefopam HCl; Nefopam hydrochloride; Fenazoxine hydrochloride; Lenipan; Oxadol; Pallopikeron, Brand name Acupan |
| In Vitro | In vitro activity: The mechanism of analgesia is not completely understood, it appears that nefopam is a centrally acting, non-opioid analgesic that inhibits reuptake of serotonin, norepinephrine, and dopamine. |
|---|---|
| In Vivo | Using the tail-flick and hot-plate assays, nefopam is tested for analgesic activity following intraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection in mice. Nefopam is one-third as potent as morphine on the hot-plate test, but does not affect the tail-flick. |
| Animal model | Mice |
| Formulation & Dosage | intraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection |
| References | Br J Anaesth. 2008 Nov;101(5):610-7. |
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