(R)-Terazosin 是一种 Terazosin 的活性 R 型对映体, 是 α1-肾上腺素受体拮抗剂，对 α1a，α1b和α1d-肾上腺素受体的Ki分别为 6.51 nM，1.01 nM 和 1.97 nM。

(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively).

(R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor(Ki of 3.85 μM, 0.33 μM and 0.37 μM, respectively). (R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues.

(R)-Terazosin shows antagonism of at rat atrial α2B receptor (pEC30 : 5.69). (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor (pA2 of 7.5 and 5.31, respectively).

109351-34-0

C19H25N5O4

387.43

(R)-特拉唑嗪;盐酸特拉唑嗪;(R)-Terazosin

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