Guanabenz hydrochloride 是一种具有降血压作用的口服活性 α2-肾上腺素受体激动剂。

Guanabenz hydrochloride is an orally active α2-adrenoceptor agonist with hypotensive effects.

Maximum concentrations of guanabenz hydrochloride in plasma (1.2 to 5.2 ng/ml) reached 2 to 5 hours after administration of capsules containing 16 or 32 mg of 14C-labelled guanabenz hydrochloride. Guanabenz hydrochloride was 90% bound to human plasma proteins. Guanabenz hydrochloride competed for imidazoline I2-binding sites in brown adipose tissue with Ki of 97 nM.

23113-43-1

C8H9Cl3N4

267.54

NE56490;Guanabenz hydrochloride

DMSO:55 mg/ml (205.58 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years