Acebutolol hydrochloride 是一种 β-肾上腺素受体拮抗剂，用于研究高血压、心绞痛和心律失常。

Acebutolol acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol Hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.

在Sprague-Dawley大鼠中,用30 mg/kg Acebutolol处理1 min和10 min后测量,心输出量分别下降65% 和 31%,大部分器官的局部血流量也显著降低.在大鼠体内,单独给10 mg/kg或50 mg/kg Acebutolol（i.v.）,其血浆清除率分别为61.9mL/min/kg和46.5 mL/min/kg,分布容积为9.6L/kg和9.5L/kg,消除半衰期为1.8 h和2.3 h.

在J774巨噬细胞中,与氧烯洛尔（与LDL结合）和Alprenolol相比,Acebutolol（不与LDL结合）对细胞内胆固醇酯积累的抑制效果更强。Acebutolol对大鼠脑P2片段摄取NA具有抑制作用（IC50：0.25 mM）。CYP（125I标记）结合到人体脂肪细胞膜的过程会被Acebutolol抑制,且它能取代所有特异性结合的放射性配体。1 μM异丙肾上腺素诱导脂肪分解的活性可被Acebutolol完全抑制。

34381-68-5

C18H29ClN2O4

372.89

Acebutolol HCl;盐酸醋丁洛尔;Acebutolol hydrochloride

Ethanol:70 mg/mL (187.7 mM)
H2O:69 mg/mL (185 mM)
DMSO:70 mg/mL (187.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years