Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-Prostaglandin F2α (ent-8-iso-15(S)-PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively. This isoprostane is about ten-fold more potent than 8-iso-PGF2α in a whole blood platelet aggregation inhibition assay.

214748-66-0

C20H34O5

354.487

ent-8-iso-15(S)-Prostaglandin F2α;ent-8-iso-15(S)-Prostaglandin F2α

DMF:>100 mg/mL
PBS (pH 7.2):>10 mg/mL
DMSO:>100 mg/mL
10 mM Na2CO3:>6.5 mg/mL
Ethanol:>100 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years