Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM).[2] It induces cell death in HAP1 cells when used at a concentration of 5 µM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine . [1] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect that can be blocked by the reducing agent β-mercaptoethanol (EC50 = >20 µM). [3] It increases lipid peroxidation in HT-1080 cells when used at a concentration of 1 µM.

1695533-44-8

C36H35ClN4O4

623.15

Erastin2;Erastin2

DMF:10 mg/mL
DMSO:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years